一对十二岁的双胞胎男孩 Zack(Dylan Sprouse)和Cody(Cole Sprouse)还有他们的妈妈是这所波斯顿高档Tipton酒店的长期住客。在这里，他们认识了新朋友London(Brenda Song)和Maddie(Ashley Tisdale)。Zack和Cody接二连三的恶作剧把Tipton旅馆变成了他们的游乐场。在搞笑、捣蛋、引发混乱的同时，也带着London和 Maddie疯了一回。Outrageous shenanigans ensue when 12-year-old twin boys Zack (Dylan Sprouse) and Cody (Cole Sprouse) turn the upscale Boston hotel where they live (The Tipton) into their own personal playground. Living in a suite with their mom Carey, the boys often take their new friends London and Maddie along for the ride, as they cause mischief, mayhem, and various catastrophes in their elegant new digs.